Barbiturates Poisoning
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Basics
Description
- Class of sedative–hypnotic agents
- Derivatives of barbituric acid
- Mechanism:
- Enhances activity of γ-aminobutyric acid (GABA)
- At high levels, directly opens GABA-A associated chloride channel
- Leads to inhibition of vascular smooth muscle tone
- May lead to direct myocardial depression
Etiology
Overdose of barbiturates:- Intentional or nonintentional
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Basics
Description
- Class of sedative–hypnotic agents
- Derivatives of barbituric acid
- Mechanism:
- Enhances activity of γ-aminobutyric acid (GABA)
- At high levels, directly opens GABA-A associated chloride channel
- Leads to inhibition of vascular smooth muscle tone
- May lead to direct myocardial depression
Etiology
Overdose of barbiturates:- Intentional or nonintentional
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