Barbiturates Poisoning
Basics
Description
Description
- Class of sedative–hypnotic agents
- Derivatives of barbituric acid
- Mechanism:
- Enhances activity of γ-aminobutyric acid (GABA)
- At high levels, directly opens GABA-A associated chloride channel
- Leads to inhibition of vascular smooth muscle tone
- May lead to direct myocardial depression
Etiology
Overdose of barbiturates:Etiology
- Intentional or nonintentional
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Citation
Schaider, Jeffrey J., et al., editors. "Barbiturates Poisoning." 5-Minute Emergency Consult, 6th ed., Lippincott Williams & Wilkins, 2020. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning.
Barbiturates Poisoning. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning. Accessed October 15, 2024.
Barbiturates Poisoning. (2020). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (6th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning
Barbiturates Poisoning [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. [cited 2024 October 15]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Barbiturates Poisoning
ID - 307529
ED - Barkin,Adam Z,
ED - Shayne,Philip,
ED - Rosen,Peter,
ED - Schaider,Jeffrey J,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning
PB - Lippincott Williams & Wilkins
ET - 6
DB - Emergency Central
DP - Unbound Medicine
ER -