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Carbapenem-resistant enterobacteriaceae (CRE)

Carbapenem-resistant enterobacteriaceae (CRE) is a topic covered in the Guide to Diagnostic Tests.

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Organism

Carbapenem-resistant enterobacteriaceae (CRE)

Carbapenemase production in the Enterobacteriaceae was unknown until early 2000s. Almost all carbapenem-resistant isolates were sporadic cases of hyperproduction of a beta-lactamase (AmpC or ESBL) combined with porin loss.

In 2001, there was the first report of carbapenem-resistant Klebsiella pneumoniae ; it carried a new carbapenemase, KPC enzyme.

New Delhi metallo-beta-lactamase (NDM1) has been described in patients infected with Escherichia coli or Klebsiella pneumoniae during surgery in India and Pakistan.

Outbreaks have been seen worldwide since 2003 of OXA-48 carbapenemase in K. pneumoniae , resulting in resistance to all beta-lactams.

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Citation

McPhee, Stephen J., et al. "Carbapenem-resistant Enterobacteriaceae (CRE)." Guide to Diagnostic Tests, 7th ed., McGraw-Hill Education, 2017. Emergency Central, emergency.unboundmedicine.com/emergency/view/GDT/619589/all/Carbapenem_resistant_enterobacteriaceae__CRE_.
McPhee SJ, Lu CM, Nicoll D. Carbapenem-resistant enterobacteriaceae (CRE). Guide to Diagnostic Tests. 7th ed. McGraw-Hill Education; 2017. https://emergency.unboundmedicine.com/emergency/view/GDT/619589/all/Carbapenem_resistant_enterobacteriaceae__CRE_. Accessed August 17, 2019.
McPhee, S. J., Lu, C. M., & Nicoll, D. (2017). Carbapenem-resistant enterobacteriaceae (CRE). In Guide to Diagnostic Tests. Available from https://emergency.unboundmedicine.com/emergency/view/GDT/619589/all/Carbapenem_resistant_enterobacteriaceae__CRE_
McPhee SJ, Lu CM, Nicoll D. Carbapenem-resistant Enterobacteriaceae (CRE) [Internet]. In: Guide to Diagnostic Tests. McGraw-Hill Education; 2017. [cited 2019 August 17]. Available from: https://emergency.unboundmedicine.com/emergency/view/GDT/619589/all/Carbapenem_resistant_enterobacteriaceae__CRE_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Carbapenem-resistant enterobacteriaceae (CRE) ID - 619589 A1 - McPhee,Stephen J, AU - Lu,Chuanyi Mark, AU - Nicoll,Diana, BT - Guide to Diagnostic Tests UR - https://emergency.unboundmedicine.com/emergency/view/GDT/619589/all/Carbapenem_resistant_enterobacteriaceae__CRE_ PB - McGraw-Hill Education ET - 7 DB - Emergency Central DP - Unbound Medicine ER -