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Syphilis

Syphilis is a topic covered in the Diagnosaurus.

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DDx

Primary syphilis (genital ulcer)

  • Herpes simplex virus (HSV)
  • Chancroid
  • Granuloma inguinale
  • Lymphogranuloma venereum
  • Trauma
  • Neoplasm
  • Behçet’s syndrome
  • Systemic lupus erythematosus (SLE)
  • Lichen planus
Secondary syphilis (rash, condyloma lata, lymphadenopathy)
  • Rash: pityriasis rosea, tinea corporis, psoriasis, nummular eczema, viral exanthem, drug eruption, lichen planus, discoid lupus erythematosus
  • Condyloma lata: genital warts (condyloma acuminata), vulvar cancer
Tertiary syphilis (neurosyphilis, cardiovascular, gummas)
  • Gummas: skin cancer; lipomas; sarcoidosis; ulcer due to pyoderma gangrenosum, vasculitis, mycobacterial infection, deep fungal infection, yaws
  • Aortic root disease: Marfan syndrome, aortic dissection, temporal (giant cell) arteritis, ankylosing spondylitis, syphilis, Reiter’s syndrome (reactive arthritis), cystic medial necrosis, sinus of Valsalva aneurysm, relapsing polychondritis
  • Neurosyphilis: primary neurologic lesions or other chronic meningitis

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Last updated: December 1, 2014

Citation

Zeiger, Roni F.. "Syphilis." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114976/all/Syphilis.
Zeiger RF. Syphilis. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114976/all/Syphilis. Accessed June 27, 2019.
Zeiger, R. F. (2014). Syphilis. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114976/all/Syphilis
Zeiger RF. Syphilis [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 June 27]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114976/all/Syphilis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Syphilis ID - 114976 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114976/all/Syphilis PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -