Acute tubular necrosis

Etiology

  • Toxins: NSAIDs, antibiotics, contrast, multiple myeloma, rhabdomyolysis, hemolysis, chemotherapy, hyperuricemia, cyclosporine
  • Ischemia, e.g., prolonged prerenal azotemia

DDx

  • Prerenal azotemia, eg, dehydration
  • Postrenal azotemia, eg, benign prostatic hyperplasia
  • Other renal causes of acute renal failure
    • Acute glomerulonephritis: immune complex (eg, IgA nephropathy), pauci-immune (eg, Wegener’s granulomatosis), anti-GBM disease
    • Acute interstitial nephritis: drugs (eg, β-lactams), infections (eg, Streptococcus), immune (eg, systemic lupus erythematosus)

See related DDx

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Last updated: December 1, 2014