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Acute tubular necrosis

Etiology

  • Toxins: NSAIDs, antibiotics, contrast, multiple myeloma, rhabdomyolysis, hemolysis, chemotherapy, hyperuricemia, cyclosporine
  • Ischemia, e.g., prolonged prerenal azotemia

DDx

  • Prerenal azotemia, eg, dehydration
  • Postrenal azotemia, eg, benign prostatic hyperplasia
  • Other renal causes of acute renal failure
    • Acute glomerulonephritis: immune complex (eg, IgA nephropathy), pauci-immune (eg, Wegener’s granulomatosis), anti-GBM disease
    • Acute interstitial nephritis: drugs (eg, β-lactams), infections (eg, Streptococcus), immune (eg, systemic lupus erythematosus)

See related DDx

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Last updated: December 1, 2014

Citation

Zeiger, Roni F.. "Acute Tubular Necrosis." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114957/all/Acute_tubular_necrosis.
Zeiger RF. Acute tubular necrosis. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114957/all/Acute_tubular_necrosis. Accessed April 20, 2019.
Zeiger, R. F. (2014). Acute tubular necrosis. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114957/all/Acute_tubular_necrosis
Zeiger RF. Acute Tubular Necrosis [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 20]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114957/all/Acute_tubular_necrosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Acute tubular necrosis ID - 114957 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114957/all/Acute_tubular_necrosis PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -