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Peripheral neuropathy (polyneuropathy)

Peripheral neuropathy (polyneuropathy) is a topic covered in the Diagnosaurus.

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Emergency Central

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Metabolic & Systemic

  • Diabetes mellitus
  • Alcoholism
  • Uremia
  • Thiamine deficiency
  • Vitamin B12 deficiency
  • Multiple myeloma
  • Amyloidosis
  • Cryoglobulinemia
  • Hypothyroidism or hyperthyroidism
  • Sarcoidosis
  • Paraneoplastic syndrome, eg, lung cancer
  • Neuropathy associated with critical illness
Infectious & Inflammatory
  • Hansen’s disease (leprosy)
  • Lyme disease
  • Diphtheritic neuropathy
  • Polyarteritis nodosa
  • Rheumatoid arthritis
  • Temporal (giant cell) arteritis
  • Metals: lead, mercury, arsenic, thallium
  • Drugs: isoniazid, phenytoin, pyridoxine, nitrofurantoin, vincristine
  • Industrial agents or pesticides: acrylamide, organophosphates, hexacarbon solvents, methyl bromide, carbon disulfide
  • Charcot-Marie-Tooth disease (hereditary motor and sensory neuropathy, HMSN type I & II)
  • Porphyria
  • Friedrich’s ataxia
  • Dejerine-Sottas disease (HMSN type III)
  • Refsum disease (HMSN type IV)
Mostly motor
  • Guillain-Barré syndrome
  • Chronic inflammatory demyelinating polyneuropathy (CIDP)
  • Porphyria
  • Diphtheritic neuropathy
  • Toxic neuropathy
  • Poliomyelitis
  • Periodic paralysis syndrome

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Last updated: December 1, 2014


Zeiger, Roni F.. "Peripheral Neuropathy (polyneuropathy)." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114834/all/Peripheral_neuropathy__polyneuropathy_.
Zeiger RF. Peripheral neuropathy (polyneuropathy). Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114834/all/Peripheral_neuropathy__polyneuropathy_. Accessed April 18, 2019.
Zeiger, R. F. (2014). Peripheral neuropathy (polyneuropathy). In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114834/all/Peripheral_neuropathy__polyneuropathy_
Zeiger RF. Peripheral Neuropathy (polyneuropathy) [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 18]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114834/all/Peripheral_neuropathy__polyneuropathy_.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Peripheral neuropathy (polyneuropathy) ID - 114834 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114834/all/Peripheral_neuropathy__polyneuropathy_ PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -