AST/ALT > 500-1000
- Acute viral hepatitis (ALT > AST)
- Toxic hepatitis, eg, acetaminophen
- Alcoholic hepatitis (AST < ALT)
- Cirrhosis (AST > ALT)
- Vascular: right-sided congestive heart failure, shock liver, Budd-Chiari syndrome
- Biliary tract obstruction (followed by increased alkaline phosphatase and bilirubin)
- Nonalcoholic fatty liver disease (formerly NASH)
- Metabolic, eg, hemochromatosis, Wilson’s disease
- Liver abscess
- Hepatocellular or metastatic cancer
- Drugs, eg, INH, statins
- Heart or skeletal muscle injury
- Celiac sprue (ALT)
- Acetaminophen, Amanita mushroom, other toxins
- Viral, especially hepatitis A
- Right-sided heart failure
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Last updated: December 1, 2014
Zeiger, Roni F.. "AST/ALT Increased." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114726/all/AST_ALT_increased.
Zeiger RF. AST/ALT increased. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114726/all/AST_ALT_increased. Accessed October 21, 2019.
Zeiger, R. F. (2014). AST/ALT increased. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114726/all/AST_ALT_increased
Zeiger RF. AST/ALT Increased [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 October 21]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114726/all/AST_ALT_increased.
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