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Acute hepatitis

Acute hepatitis is a topic covered in the Diagnosaurus.

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Causes of acute hepatitis

  • Viral: hepatitis A, B, C*, D (in presence of B), E, infectious mononucleosis, CMV, HSV, parvovirus B19
  • Other infections, e.g., leptospirosis, secondary syphilis, brucellosis, Q fever
  • Alcoholic hepatitis
  • Toxins (predictable): acetaminophen, Amanita mushrooms, tetracycline, valproic acid
  • Toxins (idiosyncratic): INH, NSAIDs, statins, azole antifungals, halothane, ecstasy, kava
  • Vascular: right-sided CHF, shock liver, portal vein thrombosis, Budd-Chiari syndrome
  • Metabolic: Wilson’s disease, acute fatty liver of pregnancy, Reye’s syndrome
  • Autoimmune hepatitis*
  • Lymphoma or metastatic cancer*

* generally do not present acutely

Causes of cholestasis (selected)

  • Extrahepatic: choledocholithiasis, pancreatic tumor, biliary stricture, primary sclerosing cholangitis (intra- and extrahepatic)
  • Intrahepatic: primary biliary cirrhosis, autoimmune cholangitis, infiltrative disease (e.g., TB, sarcoidosis, lymphoma, amyloidosis), drugs

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Last updated: January 12, 2015


Zeiger, Roni F.. "Acute Hepatitis." Diagnosaurus, 4th ed., McGraw-Hill Education, 2015. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114699/all/Acute_hepatitis.
Zeiger RF. Acute hepatitis. Diagnosaurus. 4th ed. McGraw-Hill Education; 2015. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114699/all/Acute_hepatitis. Accessed April 24, 2019.
Zeiger, R. F. (2015). Acute hepatitis. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114699/all/Acute_hepatitis
Zeiger RF. Acute Hepatitis [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2015. [cited 2019 April 24]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114699/all/Acute_hepatitis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Acute hepatitis ID - 114699 A1 - Zeiger,Roni F, Y1 - 2015/01/12/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114699/all/Acute_hepatitis PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -