Pancytopenia

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Etiology

Bone marrow disorders

  • Aplastic anemia
  • Myelodysplastic syndrome
  • Acute leukemia
  • Myelofibrosis
  • Infiltrative disease: lymphoma, myeloma, carcinoma, hairy cell leukemia
  • Megaloblastic anemia
  • Paroxysmal nocturnal hemoglobinuria
  • Bone marrow irradiation
  • Genetic, e.g., Fanconi’s anemia
Nonmarrow disorders
  • Hypersplenism
  • Systemic lupus erythematosus
  • Infection: tuberculosis, AIDS, leishmaniasis, brucellosis, histoplasmosis. (Viruses causing aplastic anemia: hepatitis, Epstein-Barr virus, HIV, parvovirus B19)

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Etiology

Bone marrow disorders

  • Aplastic anemia
  • Myelodysplastic syndrome
  • Acute leukemia
  • Myelofibrosis
  • Infiltrative disease: lymphoma, myeloma, carcinoma, hairy cell leukemia
  • Megaloblastic anemia
  • Paroxysmal nocturnal hemoglobinuria
  • Bone marrow irradiation
  • Genetic, e.g., Fanconi’s anemia
Nonmarrow disorders
  • Hypersplenism
  • Systemic lupus erythematosus
  • Infection: tuberculosis, AIDS, leishmaniasis, brucellosis, histoplasmosis. (Viruses causing aplastic anemia: hepatitis, Epstein-Barr virus, HIV, parvovirus B19)

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