Primary amenorrhea
Etiology
Hypothalamic-pituitary causes (low-normal FSH)
- Idiopathic delayed puberty
- Pituitary tumor
- Hypothalamic amenorrhea, eg, stress, weight change, exercise
- Anorexia nervosa
- Hypothyroidism
- Cushing's syndrome
- GnRH or gonadotropin deficiency, eg, Kallmann syndrome
- Craniopharyngioma
Excess testosterone (low-normal FSH)
- Adrenal tumor or adrenal hyperplasia
- Polycystic ovary syndrome
- Ovarian tumor
- Androgenic steroids
Ovarian causes (high FSH)
- Gonadal dysgenesis, eg, Turner syndrome
- Autoimmune ovarian failure
- Rare ovarian enzyme deficiencies
Pseudohermaphroditism (high LH)
- Testosterone synthesis defect
- Complete androgen resistance (testicular feminization)
Anatomic defect (normal FSH)
- Vaginal agenesis, absent uterus, atrophic endometrium, imperforate hymen
Pregnancy (high hCG)
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Last updated: December 1, 2014
Citation
Zeiger, Roni F.. "Primary Amenorrhea." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114541/all/Primary_amenorrhea.
Zeiger RFR. Primary amenorrhea. Diagnosaurus. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114541/all/Primary_amenorrhea. Accessed October 11, 2024.
Zeiger, R. F. (2014). Primary amenorrhea. In Diagnosaurus (4th ed.). McGraw-Hill Education. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114541/all/Primary_amenorrhea
Zeiger RFR. Primary Amenorrhea [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2024 October 11]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114541/all/Primary_amenorrhea.
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