Splenomegaly
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DDx
- Infections, eg, mononucleosis (Epstein-Barr virus), cytomegalovirus, acute HIV, endocarditis, histoplasmosis, malaria, schistosomiasis, leishmaniasis, filariasis
- Chronic hemolytic anemia
- Leukemia
- Lymphoma
- Extramedullary hematopoiesis, eg, myelofibrosis, marrow toxin
- Polycythemia vera
- Essential thrombocytosis
- Cirrhosis or noncirrhotic portal hypertension
- Congestive heart failure
- Immune thrombocytopenias
- Splenic vein thrombosis
- Rheumatoid arthritis (Felty’s syndrome)
- Systemic lupus erythematosus
- Sarcoidosis
- Wilson’s disease
- Amyloidosis
- Budd-Chiari syndrome
- Gaucher disease
- Niemann-Pick disease
- Splenic cysts, hemangiomas, hamartomas, fibromas
- Metastases, eg, melanoma
- Eosinophilic granuloma (Langerhans cell histiocytosis, histiocytosis X)
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DDx
- Infections, eg, mononucleosis (Epstein-Barr virus), cytomegalovirus, acute HIV, endocarditis, histoplasmosis, malaria, schistosomiasis, leishmaniasis, filariasis
- Chronic hemolytic anemia
- Leukemia
- Lymphoma
- Extramedullary hematopoiesis, eg, myelofibrosis, marrow toxin
- Polycythemia vera
- Essential thrombocytosis
- Cirrhosis or noncirrhotic portal hypertension
- Congestive heart failure
- Immune thrombocytopenias
- Splenic vein thrombosis
- Rheumatoid arthritis (Felty’s syndrome)
- Systemic lupus erythematosus
- Sarcoidosis
- Wilson’s disease
- Amyloidosis
- Budd-Chiari syndrome
- Gaucher disease
- Niemann-Pick disease
- Splenic cysts, hemangiomas, hamartomas, fibromas
- Metastases, eg, melanoma
- Eosinophilic granuloma (Langerhans cell histiocytosis, histiocytosis X)
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