Protein-losing enteropathy

Etiology

Mucosal disease with ulceration

  • Chronic gastric ulcer
  • Gastric carcinoma
  • Lymphoma
  • Inflammatory bowel disease
  • Idiopathic ulcerative jejunoileitis
Lymphatic obstruction
  • Primary intestinal lymphangiectasia
  • Secondary obstruction: cardiac disease (constrictive pericarditis, congestive heart failure), infection (tuberculosis, Whipple’s disease), neoplasm (lymphoma, Kaposi’s sarcoma), retroperitoneal fibrosis, sarcoidosis
Idiopathic mucosal transudation
  • Ménétrier’s disease (hypertrophic gastropathy)
  • Zollinger-Ellison syndrome (gastrinoma)
  • Viral gastroenteritis
  • Celiac sprue
  • Eosinophilic gastroenteritis
  • Allergic protein-losing enteropathy
  • Parasites, eg, giardiasis, hookworm
  • Amyloidosis
  • Common variable immunodeficiency
  • Systemic lupus erythematosus

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Last updated: December 1, 2014