Fever in immunocompromised patient

DDx

Neutropenia

  • Gram-negative enteric organisms
  • Pseudomonas
  • Gram-positive cocci, eg, S. aureus, S. epidermidis
  • Candida
  • Aspergillus and other fungi
Cellular immune defect (HIV, lymphoma, immunosuppressive drugs)
  • Bacteria: Listeria, Legionella, Salmonella, Mycobacterium
  • Viruses: herpes simplex virus, varicella, cytomegalovirus
  • Fungi: Cryptococcus, Coccidioides, Histoplasma, Pneumocystis
  • Protozoa: Toxoplasma
Humoral immune defect (congenital, multiple myeloma, chronic lymphocytic leukemia)
  • Encapsulated organisms: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis
Asplenia (functional or anatomic)
  • Encapsulated organisms: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis
Noninfectious causes
  • Transplant rejection
  • Organ ischemia or necrosis
  • Thrombophlebitis
  • Lymphoma

See related DDx

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Last updated: December 1, 2014

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TY - ELEC T1 - Fever in immunocompromised patient ID - 114421 Y1 - 2014/12/01/ PB - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient ER -