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Fever in immunocompromised patient

DDx

Neutropenia

  • Gram-negative enteric organisms
  • Pseudomonas
  • Gram-positive cocci, eg, S. aureus, S. epidermidis
  • Candida
  • Aspergillus and other fungi
Cellular immune defect (HIV, lymphoma, immunosuppressive drugs)
  • Bacteria: Listeria, Legionella, Salmonella, Mycobacterium
  • Viruses: herpes simplex virus, varicella, cytomegalovirus
  • Fungi: Cryptococcus, Coccidioides, Histoplasma, Pneumocystis
  • Protozoa: Toxoplasma
Humoral immune defect (congenital, multiple myeloma, chronic lymphocytic leukemia)
  • Encapsulated organisms: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis
Asplenia (functional or anatomic)
  • Encapsulated organisms: Streptococcus pneumoniae, Haemophilus influenzae, Neisseria meningitidis
Noninfectious causes
  • Transplant rejection
  • Organ ischemia or necrosis
  • Thrombophlebitis
  • Lymphoma

See related DDx

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Last updated: December 1, 2014

Citation

Zeiger, Roni F.. "Fever in Immunocompromised Patient." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient.
Zeiger RF. Fever in immunocompromised patient. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient. Accessed April 26, 2019.
Zeiger, R. F. (2014). Fever in immunocompromised patient. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient
Zeiger RF. Fever in Immunocompromised Patient [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 26]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Fever in immunocompromised patient ID - 114421 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114421/all/Fever_in_immunocompromised_patient PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -