Acromegaly and gigantism

DDx

  • Pseudoacromegaly (acromegaly features, insulin resistance)
  • Inactive ("burned-out") acromegaly (spontaneous remission due to pituitary adenoma infarction)
  • Physiologic growth spurt
  • Familial coarse features
  • Familial large hands and feet
  • Myxedema
  • Isolated prognathism (jaw protrusion)
Gigantism
  • Familial tall stature
  • Aromatase deficiency
  • Estrogen receptor deficiency
Increased growth hormone level
  • Exercise or eating prior to test, acute illness or agitation, hepatic or renal failure, malnourishment, diabetes mellitus, estrogens, beta blockers, clonidine

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Last updated: December 1, 2014