Palms and soles rash
DDx
- Tinea
 - Warts
 - Dyshidrotic eczema (pomphylox, dyshidrosis)
 - Secondary syphilis
 - Dermatophytid reaction (allergy or sensitivity to fungi)
 - Erythema multiforme
 - Rocky Mountain spotted fever
 - Drug eruption
 - Janeway lesions or Osler's nodes (bacterial endocarditis)
 - Cholesterol emboli
 - Contact dermatitis (palms)
 - Pitted keratolysis (soles)
 - Keratoderma blennorrhagica (with reactive arthritis or Reiter's syndrome)
 - Psoriasis
 - Gonococcemia or meningococcemia
 - Hand, foot, and mouth disease
 - Toxic shock syndrome
 - Lichen planus (ulcerative)
 - Melanoma
 - Calluses or corns
 - Rat-bite fever
 - Arsenic poisoning
 
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Last updated: December 1, 2014
Citation
Zeiger, Roni F.. "Palms and Soles Rash." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114234/all/Palms_and_soles_rash. 
Zeiger RFR. Palms and soles rash. Diagnosaurus. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114234/all/Palms_and_soles_rash. Accessed November 4, 2025.
Zeiger, R. F. (2014). Palms and soles rash. In Diagnosaurus (4th ed.). McGraw-Hill Education. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114234/all/Palms_and_soles_rash
Zeiger RFR. Palms and Soles Rash [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2025 November 04]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114234/all/Palms_and_soles_rash.
* Article titles in AMA citation format should be in sentence-case
TY  -  ELEC
T1  -  Palms and soles rash
ID  -  114234
A1  -  Zeiger,Roni F,
Y1  -  2014/12/01/
BT  -  Diagnosaurus
UR  -  https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114234/all/Palms_and_soles_rash
PB  -  McGraw-Hill Education
ET  -  4
DB  -  Emergency Central
DP  -  Unbound Medicine
ER  -  

Diagnosaurus

