Generalized lymphadenopathy
DDx
Infection
- Viral, eg, infectious mononucleosis (Epstein-Barr virus, cytomegalovirus), hepatitis, herpes simplex virus, varicella, rubella, acute HIV infection or AIDS
- Bacterial, eg, streptococci, staphylococci, cat-scratch disease, tuberculosis, syphilis, tularemia, chancroid, plague, leprosy
- Fungal, eg, histoplasmosis, coccidioidomycosis
- Chlamydial, eg, lymphogranuloma venereum
- Parasitic, eg, toxoplasmosis, leishmaniasis, trypanosomiasis, filariasis
- Rickettsial, eg, scrub typhus
- Hodgkin’s or non-Hodgkin’s lymphoma
- Leukemia
- Metastatic cancer
- Virchow’s (left supraclavicular) node: gastrointestinal (classically gastric) cancer
- Sister Mary Joseph (umbilical) node: gastrointestinal cancer
- Right subclavian node: lung cancer
- Rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, Sjögren’s syndrome
- Drug hypersensitivity
- Serum sickness
- Sarcoidosis
- Amyloidosis
- Lipid storage disease, eg, Gaucher, Niemann-Pick
- Hyperthyroidism
- Castleman’s disease (giant lymph node hyperplasia)
- Dermatopathic lymphadenitis
- Kikuchi’s disease (histiocytic necrotizing lymphadenitis)
- Kawasaki disease
- Eosinophilic granuloma (Langerhans cell histiocytosis, histiocytosis X)
- Familial Mediterranean fever
- Drug-induced pseudolymphoma (classically phenytoin)
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Last updated: December 1, 2014
Citation
Zeiger, Roni F.. "Generalized Lymphadenopathy." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114139/all/Generalized_lymphadenopathy.
Zeiger RFR. Generalized lymphadenopathy. Diagnosaurus. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114139/all/Generalized_lymphadenopathy. Accessed October 12, 2024.
Zeiger, R. F. (2014). Generalized lymphadenopathy. In Diagnosaurus (4th ed.). McGraw-Hill Education. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114139/all/Generalized_lymphadenopathy
Zeiger RFR. Generalized Lymphadenopathy [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2024 October 12]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114139/all/Generalized_lymphadenopathy.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Generalized lymphadenopathy
ID - 114139
A1 - Zeiger,Roni F,
Y1 - 2014/12/01/
BT - Diagnosaurus
UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114139/all/Generalized_lymphadenopathy
PB - McGraw-Hill Education
ET - 4
DB - Emergency Central
DP - Unbound Medicine
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