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Hyperuricemia, endogenous

Hyperuricemia, endogenous is a topic covered in the Diagnosaurus.

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Primary hyperuricemia

  • Increased production of purine
  1. Idiopathic
  2. Specific enzyme defects (eg, Lesch-Nyhan syndrome, glycogen storage diseases)
  • Decreased renal clearance of uric acid (idiopathic)

Secondary hyperuricemia

  • Increased purine catabolism and turnover
  1. Myeloproliferative disorders
  2. Lymphoproliferative disorders
  3. Carcinoma and sarcoma (disseminated)
  4. Chronic hemolytic anemias
  5. Cytotoxic drugs
  6. Psoriasis
  • Decreased renal clearance of uric acid
  1. Intrinsic kidney disease
  2. Functional impairment of tubular transport:
  • Drug-induced (eg, thiazides, probenecid)
  • Hyperlacticacidemia (eg, lactic acidosis, alcoholism)
  • Hyperketoacidemia (eg, diabetic ketoacidosis, starvation)
  • Diabetes insipidus (vasopressin-resistant)
  • Bartter's syndrome

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Last updated: December 1, 2014


Zeiger, Roni F.. "Hyperuricemia, Endogenous." Diagnosaurus, 4th ed., McGraw-Hill Education, 2014. Emergency Central, emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
Zeiger RF. Hyperuricemia, endogenous. Diagnosaurus. 4th ed. McGraw-Hill Education; 2014. https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous. Accessed April 24, 2019.
Zeiger, R. F. (2014). Hyperuricemia, endogenous. In Diagnosaurus. Available from https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous
Zeiger RF. Hyperuricemia, Endogenous [Internet]. In: Diagnosaurus. McGraw-Hill Education; 2014. [cited 2019 April 24]. Available from: https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hyperuricemia, endogenous ID - 114081 A1 - Zeiger,Roni F, Y1 - 2014/12/01/ BT - Diagnosaurus UR - https://emergency.unboundmedicine.com/emergency/view/Diagnosaurus/114081/all/Hyperuricemia__endogenous PB - McGraw-Hill Education ET - 4 DB - Emergency Central DP - Unbound Medicine ER -