Trade Name(s)

  • Kerydin

Ther. Class.

Pharm. Class.


Topical treatment of toenail onychomycosis.


Inhibits fungal protein synthesis via inhibition of aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS).

Therapeutic Effect(s):

Resolution of toenail fungus.


Active against Trychophyton rubrum and Trychophyton mentagrophytes.


Absorption: Minimal absorption follows topical administration.

Distribution: Unknown.

Metabolism and Excretion: Extensively metabolized, metabolites are eliminated mostly in urine.

Half-life: Unknown.

TIME/ACTION PROFILE (resolution of infection)

Topunknownunknown48 wk†
† Length of treatment necessary for resolution of infection.


Contraindicated in:

  • None noted.

Use Cautiously in:

  • Geri:  Elderly may be more sensitive to drug effects;
  • OB:  Use during pregnancy only if potential benefit justifies potential risk to fetus
  • Use cautiously if breastfeeding;
  • Pedi:  Safe and effective use in children has not been established.

Adverse Reactions/Side Effects

Local: dermatitis, erythema, exfoliation, ingrown toenail

* CAPITALS indicate life-threatening.
Underline indicate most frequent.



None noted.


Topical (Adults): Apply to affected nail once daily for 48 wk.


Topical solution: 5% in 12-mL bottle with enclosed dropper


  • Inspect involved areas of skin and mucous membranes before and frequently during therapy. Increased skin irritation may indicate need to discontinue medication.

Potential Diagnoses


  • Topical Apply daily for 48 wks to clean, dry toenail surface and under tip of toenail. Avoid contact with skin other than skin immediately surrounding treated nail. Wipe excess solution away from surrounding skin. Allow solution to dry following application. Avoid contact with eyes or mucous membranes.

Patient/Family Teaching

  • Instruct patient to apply medication as directed for full course of therapy, even if feeling better. Emphasize the importance of avoiding the eyes. Caution patient that solution is flammable; avoid use near heat or open flame. Discard bottle 3 mo after inserting dropper. Advise patient to read  Patient Information  sheet prior to starting therapy and with each Rx refill in case of changes.
  • Advise patient to notify health care professional if area of application shows signs of persistent irritation (redness, itching, swelling, skin peeling, ingrown toenail).
  • Advise patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Resolution of toenail fungus.

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