Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.
- Premenstrual dysphoric disorder (PMDD)
- Smoking cessation.
L-tryptophan is an essential amino acid that is converted by the body to 5–hydroxytryptophan (5–HTP) and then to serotonin. Both L-tryptophan and 5–HTP cross the blood-brain barrier and have sedative effects. Depletion of endogenous tryptophan can cause a relapse in depression symptoms.
- Improved symptoms of depression.
- Improved sleep.
Metabolism and Excretion: Unknown
- Pregnancy and lactation.
Use Cautiously in:
- Kidney disease.
- Liver disease.
Adverse Reactions/Side Effects
CNS: ataxia, headache, drowsiness, lightheadedness
EENT: visual blurring
GI: heartburn, abdominal pain, dry mouth, nausea
Hemat: eosinophilia-myalgia syndrome
* CAPITALS indicate life-threatening.
Underline indicate most frequent.
Natural Drug Interaction
- Increased risk of serotonergic effects and serotonin syndrome with SSRIs, dextromethorphan, meperidine, tricyclic antidepressants, monoamine oxidase inhibitors, and tramadol .
- Increased sedation with CNS depressants .
- Additive sedation with herbs or supplements that have sedative properties such as kava St. John's wort valerian 5–HTP and others.
- Increased risk of serotonin syndrome with St. John's wort. .
PO (Adults) Insomnia– 1 gram 20 minutes before bedtime; Depression– 300 mg/day; Prementrual syndrome– 6 grams/day; Smoking cessation– 50 mg/kg/day.
Tablets: 500 mg
- Assess sleep patterns prior to and periodically during therapy.
- Monitor for signs and symptoms of esosinophilia-myalgia sydrome (severe myalgia, arthralgia, intense eosinophilia) Less common symptoms include respiratory prodrome (cough, dyspnea, pulmonary infiltrates), limb edema, scleroderma, mononeuritis, evanescent skin rash, mild LFT elevations, and leukocytosis. If these symptoms occur, discontinue l-tryptophan.
- Deficient knowledge, related to medication regimen (Patient/Family/Teaching)
- PO Administer without regard to food.
- Instruct patient to take as directed; do not take more than directed.
- Advise patient to notify health care professional of symptoms of esosinophilia-myalgia sydrome occur.
- Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.
Improvement in insomnia and premenstrual disorder.
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