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lutein

General

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

Pronunciation:
loo-tee-in

Trade Name(s)

  • carotenoid
  • xanthophyll
  • zeaxanthin

Ther. Class.
antioxidants
ocular agents

Common Uses

  • Prevention of lutein deficiency.
  • Prevention of age-related macular degeneration (AMD), cataracts, and retinitis pigmentosa.

Action

Lutein is a carotenoid with antioxidant properties that protect underlying ocular tissues from photodamage.

Therapeutic Effect(s):

Decreased risk of development of AMD and cataracts.

Pharmacokinetics

Absorption: Unknown.

Distribution: Unknown.

Metabolism and Excretion: Unknown.

Half-life: Unknown.

TIME/ACTION PROFILE

ROUTEONSETPEAKDURATION
POUnknownUnknownUnknown

Contraindication/Precautions

Contraindicated in:

  • Hypersensitivity.

Use Cautiously in:

Cystic fibrosis (decreased lutein absorption).

Adverse Reactions/Side Effects

CV: DISEASE

Endo: carotendermia

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Natural Drug Interaction

  • Orlistatmay cause ↓ lutein absorption.
  • Alcohol (↓ plasma lutein), cholestyramine and colestipol (↓ lutein absorption), CYP450-metabolized agents (alters enzyme activity), mineral oil (↓ lutein absorption), nicotine ↓ plasma lutein), retinol (↑ plasma lutein), may interact with agents with similar effects or related mechanisms of action (antidiabetic, antilipemic, antioxidant, antineoplastic), ↓ vitamin E levels.

Natural-Natural:

Concomitant administration with beta-carotene may reduce bioavailability of lutein.

Route/Dosage

PO: (Adults) 6–20 mg/day.

Availability

Softgels: 6 mg, 20 mg

Assessment

  • Obtain ophthalmic examinations at least yearly during therapy.

Potential Diagnoses

Implementation

  • PO: Administer capsules once daily.

Patient/Family Teaching

  • Instruct patient to take as directed.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
  • Advise female patient to notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

Decrease in risk or cataracts and age-related macular degeneration.

lutein is a sample topic from the Davis's Drug Guide.

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Citation

Quiring, Courtney, et al. "Lutein." Davis's Drug Guide, 16th ed., F.A. Davis Company, 2019. Emergency Central, emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109923/all/lutein.
Quiring C, Sanoski CA, Vallerand AH. Lutein. Davis's Drug Guide. 16th ed. F.A. Davis Company; 2019. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109923/all/lutein. Accessed March 19, 2019.
Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2019). Lutein. In Davis's Drug Guide. Available from https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109923/all/lutein
Quiring C, Sanoski CA, Vallerand AH. Lutein [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2019. [cited 2019 March 19]. Available from: https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109923/all/lutein.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - lutein ID - 109923 A1 - Quiring,Courtney, AU - Sanoski,Cynthia A, AU - Vallerand,April Hazard, BT - Davis's Drug Guide UR - https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109923/all/lutein PB - F.A. Davis Company ET - 16 DB - Emergency Central DP - Unbound Medicine ER -