sage

General

Complementary/Alternative Medicine: This monograph describes a natural or herbal product that is not subject to FDA guidelines for medicines. Patients and clinicians are advised to read package labels carefully to ensure safe and efficacious use.

Pronunciation:
seyj


Trade Name(s)

  • Salvia officinalis
  • common sage
  • garden sage

Ther. Class.
anti-Alzheimers's agents
anti-infectives

Common Uses

  • Alzheimer's disease.
  • Herpes labialis.

Action

Sage leaf and volatile oil contain active constituents that have antioxidant, CNS depressant, estrogenic, anti-inflammatory and anticholinesterase activity. It may also have hypoglycemic activity. Sage also contains camphor which can cause neurotoxicity and hepatotoxicity in high doses.

Therapeutic Effect(s):

Improved cognitive function in Alzheimer's disease.

Pharmacokinetics

Absorption: Unknown

Distribution: Unknown

Metabolism and Excretion: Unknown

Half-life: Unknown

TIME/ACTION PROFILE

ONSETPEAKDURATION
POunknownunknownunknown

Contraindication/Precautions

Contraindicated in:

  • Hypersensitivity;
  • Pregnancy and lactation.

Use Cautiously in:

  • Seizure disorders;
  • Hypertension;
  • Diabetes

Adverse Reactions/Side Effects

CV: hypertension

CNS: dizziness, agitation, seizures (high doses)

GI: nausea, vomiting, abdominal pain, hepatotoxicity (high doses)

Resp: wheezing

* CAPITALS indicate life-threatening.
Underline indicate most frequent.

Interactions

Natural Drug Interaction

  • Additive effects with hypoglycemic agentsand CNS depressants.
  • May interfere with the effectiveness of anticonvulsants..

Natural-Natural:

  • Additive effects with herbs that have hypoglycemic potential such as fenugreekgarlicginsengand psyllium..
  • Additive effects with herbs that have sedative properties such as 5–HTPkavaSt. John's wortvalerianand others.

Route/Dosage

PO: (Adults)Alzheimer's disease–1 gram/day of extract.

Topical:(Adults)Herpes labialis–apply cream with 23 mg/gram of sage extract every 2–4 hours while awake starting within 1 day of the first symptoms and continuing for 10 to 14 days.

Availability

Extract:
Cream : 23 mg/gram sage extract in combination with rhubarb extract

Assessment

  • Monitor BP periodically during therapy.
  • Assess memory and cognitive function periodically during therapy.
  • Assess lesions prior to and periodically during therapy.

Lab Test Considerations:

Monitor: blood glucose periodically during therapy.

Potential Diagnoses

Implementation

  • PO: Administer as directed.
  • Topical:Apply to lesions every 2–4 hrs while awake.

Patient/Family Teaching

  • Instruct patient how to take or administer sage.
  • Instruct patient to notify health care professional of all Rx or OTC medications, vitamins, or herbal products being taken and to consult with health care professional before taking other medications.
  • Advice female patient to avoid taking more than is in normal food intake. Notify health care professional if pregnancy is planned or suspected or if breastfeeding.

Evaluation/Desired Outcomes

  • Improved cognitive function in patients with Alzheimer's disease.
  • Healing of lesions in herpes labialis.
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