Equianalgesic Dosing Guidelines
OPIOID ANALGESICS STARTING ORAL DOSE COMMONLY USED FOR SEVERE PAIN
EQUIANALGESIC DOSE | STARTING ORAL DOSE | ||||||||
---|---|---|---|---|---|---|---|---|---|
NAME | ORAL* | PARENTERAL† | ADULTS | CHILDREN | COMMENTS | PRECAUTIONS AND CONTRAINDICATIONS | |||
Morphine-like agonists (mu agonists) | |||||||||
morphine | 30 mg | 10 mg | 15–30 mg | 0.3 mg/kg | Standard of comparison for opioid analgesics. Sustained release preparations (MS Contin) release over 8–12 hr. Other formulations (, MS Contin) last 12–24 hr. Generic sustained release morphine preparations are now available. | For all opioids, caution in patients with impaired ventilation, bronchial asthma, ↑ intracranial pressure, liver failure. | |||
hydromorphone (Dilaudid) | 7.5 mg | 1.5 mg | Opioid naïve: 4–8 mg | 0.06 mg/kg | Slightly shorter duration than morphine. Sustained release preparations release over 24 hr. | ||||
fentanyl | – | 0.1 mg | – | – | |||||
oxycodone | 20 mg | – | 10–20 mg | 0.2 mg/kg | |||||
methadone | 10 mg | 5 mg | 5–10 mg | 0.2 mg/kg | Good oral potency, long plasma half-life (24–36 hr). | Accumulates with repeated dosing, requiring decreases in dose size and frequency, especially on days 2–5. Use with caution in older adults. | |||
levorphanol | 2 mg (acute), 1 mg (chronic) | – | 2–4 mg | 0.04 mg/kg | Long plasma half-life (12–16 hr, but may be as long as 90–120 hr after one wk of dosing). | Accumulates on days 2 and 3. Use with caution in older adults. | |||
oxymorphone (Opana) | 10 mg | – | – | – | – | ||||
meperidine (Demerol) | 300 mg | 100 mg | Not Recommended | – | Slightly shorter acting than morphine; accumulates with repetitive dosing causing CNS excitation; avoid in children with impaired renal function or who are receiving monoamine oxidase inhibitors.‡ | Use with caution. Normeperidine (toxic metabolite) accumulates with repetitive dosing causing CNS excitation and a high risk of seizure. Avoid in children, renal impairment, and patients on monoamine oxidase inhibitors.‡ | |||
Centrally acting mu agonists | |||||||||
tramadol (Ultram), ConZip | 120 mg | – | 50–100 mg every 4–6 hr | – | Prodrug; significant serotonin reuptake inhibition. Maximum dose: IR 400 mg/day; ER 300 mg/day. | Caution with pre-existing seizure disorder, concurrent use of medications that ↓ seizure threshold, or medications that ↑ risk of serotonin syndrome. | |||
tapentadol (Nucynta) | 100 mg | – | 50–100 mg every 4–6 hr | – | Sustained release preparation (Nucynta ER) releases over 12 hr. Blocks reuptake of norepinephrine > serotonin. | Caution with pre-existing seizure disorder or concurrent use of medications that ↓ seizure threshold. | |||
Mixed agonists–antagonists (kappa agonists) | |||||||||
nalbuphine | – | 10 mg | 10 mg every 3–6 hr | 0.1–0.2 mg/kg every 3–4 hr | Not available orally; not scheduled under Controlled Substances Act. Kappa agonist, partial mu antagonist. | Incidence of psychotomimetic effects lower than with pentazocine; may precipitate withdrawal in opioid-dependent patients. | |||
butorphanol | – | 2 mg | 1–4 mg every 3–4 hr (IM); 0.5–2 mg every 3–4 hr (IV) | – | Kappa agonist, partial mu antagonist. Also available in nasal spray. | Likenalbuphine. | |||
Partial agonist | |||||||||
buprenorphine (Buprenex) | – | 0.4 mg | 0.3 mg every 6–8 hr (IM/IV) | 2–12 yr: 0.2–0.6 mg every 4–6 hr (IM/IV) | Sublingual tablets now available both plain and with naloxone for opioid-dependent patient management for specially certified physicians. These tablets are not approved as analgesics. Also available as a long-acting transdermal patch (Butrans), and buccal film (, Belbuca). | May precipitate withdrawal in opioid-dependent patients; not readily reversed by naloxone; avoid in labor. | |||
*Starting dose should be lower for older adults. †These are standard parenteral doses for acute pain in adults and can also be used to convert doses for IV infusions and repeated small IV boluses. For single IV boluses, use half the IM dose. IV doses for children >6 mo. = parenteral equianalgesic dose times weight (kg)/100. ‡Irritating to tissues with repeated IM injections. Kishner, S. (2022). Opioid equivalents and conversions. Medscape. https://emedicine.medscape.com/article/2138678-overview?form;eqfpf |
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Citation
Vallerand, April Hazard., et al. "Equianalgesic Dosing Guidelines." Davis's Drug Guide, 19th ed., F.A. Davis Company, 2024. Emergency Central, emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines.
Vallerand AHA, Sanoski CAC, Quiring CC. Equianalgesic Dosing Guidelines. Davis's Drug Guide. F.A. Davis Company; 2024. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines. Accessed November 7, 2024.
Vallerand, A. H., Sanoski, C. A., & Quiring, C. (2024). Equianalgesic Dosing Guidelines. In Davis's Drug Guide (19th ed.). F.A. Davis Company. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines
Vallerand AHA, Sanoski CAC, Quiring CC. Equianalgesic Dosing Guidelines [Internet]. In: Davis's Drug Guide. F.A. Davis Company; 2024. [cited 2024 November 07]. Available from: https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines.
* Article titles in AMA citation format should be in sentence-case
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AU - Vallerand,April Hazard,
AU - Quiring,Courtney,
BT - Davis's Drug Guide
UR - https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/109510/all/Equianalgesic_Dosing_Guidelines
PB - F.A. Davis Company
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DB - Emergency Central
DP - Unbound Medicine
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