Parkinson Disease
Parkinson Disease is a topic covered in the 5-Minute Emergency Consult.
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Basics
Description
Description
- Gradual progressive neurologic disorder of middle or late life
- Degeneration of dopaminergic neurons in the substantia nigra
- Development of Lewy bodies in the residual dopaminergic neurons
- Accelerated cortical atrophy
- Can begin unilaterally, but generalizes to symmetric
- Affects 1% of people >60 yr; 4% >80 yr
- May have symptoms 20 yr prior to diagnosis
- Nonspecific:
- Fatigue
- Constipation
- Hyposomia
- Nonspecific:
Etiology
Etiology
- Sporadic or idiopathic
- Disorders presenting with parkinsonism:
- Drug induced:
- Parkinsonism-hyperpyrexia syndrome (dopaminergic drug withdrawal)
- Amphotericin B
- Chemotherapeutic drugs
- Neuroleptic treatment induced
- Toxins:
- Carbon monoxide
- Methanol
- Cyanide
- Organophosphate poisoning
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Brain lesions:
- Basal ganglia stroke
- Midbrain lesions
- Hydrocephalus
- Infections:
- Mycoplasma
- Viral encephalitis
- Other:
- Central pontine myelinosis
- Encephalitis lethargica (autoantibodies against basal ganglia antigens)
- Drug induced:
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Citation
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TY - ELEC
T1 - Parkinson Disease
ID - 307675
ED - Barkin,Adam Z,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Rosen,Peter,
ED - Schaider,Jeffrey J,
ED - Shayne,Philip,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307675/all/Parkinson_Disease
PB - Lippincott Williams & Wilkins
ET - 5
DB - Emergency Central
DP - Unbound Medicine
ER -