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Henoch–schönlein Purpura

Henoch–schönlein Purpura is a topic covered in the 5-Minute Emergency Consult.

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Basics

Description

Vasculitis

Etiology

Mechanism:
  • Increased serum IgA:
    • Circulating IgA complexes
    • Glomerular mesangial deposition of IgA
  • Although cause is undefined, there are many associated conditions:
    • Infections
    • Group A streptococcus
    • Mycoplasma
    • Viral: Varicella, Epstein–Barr (EB)
    • Drugs: Penicillin, tetracycline, aspirin, sulfonamides, erythromycin
    • Allergens: Insect bites, chocolate, milk, wheat
  • Peak incidence: School-aged children and young adults
  • More common in whites
  • Males > females
  • Occurs more often in winter/spring
  • Multisystem involvement can lead to life-threatening or long-term complications:
    • Intussusception
    • Proliferative glomerulonephritis
    • Chronic renal failure:
    • More common in older children and adults (13–14%)
    • Intracranial hemorrhage

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Citation

Rosen, Peter, et al., editors. "Henoch–schönlein Purpura." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307672/all/Henoch–schönlein_Purpura.
Henoch–schönlein Purpura. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307672/all/Henoch–schönlein_Purpura. Accessed April 26, 2019.
Henoch–schönlein Purpura. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307672/all/Henoch–schönlein_Purpura
Henoch–schönlein Purpura [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 26]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307672/all/Henoch–schönlein_Purpura.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Henoch–schönlein Purpura ID - 307672 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307672/all/Henoch–schönlein_Purpura PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -