- Idiopathic avascular necrosis of the femoral head in children 4–12 yr
- Increased frequency with factor V Leiden and anticardiolipin antibodies
- Usually sporadic but small percentage associated with type 2 collagen COL2A1 gene mutations
Exclusively a pediatric disease
- Idiopathic avascular necrosis from interruption of blood supply to the femoral head from ischemia/occlusion, followed by reossification, deformity, and mechanically weakened bone
- May be multifactorial
- Risk factors include secondhand exposure to tobacco smoke, wood smoke, low birth weight, birth length <50 cm, delayed skeletal maturity, trauma, coagulation disorders
- Gradual progression through 4 stages of disease:
- Initial stage: Dense femoral head causing intermittent synovitis
- Fragmentation: Femoral head becomes soft and deforms causing loss of motion
- Healing: New bone grows into femoral head
- Residual: Healed femoral head with some deformity
- Most commonly occurs between ages 3–7; male > female, 4:1; Caucasians
- Typically unilateral, but bilateral in 10–15% of cases
- Associated with short stature, delayed and disproportionate growth
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Schaider, Jeffrey J., et al., editors. "Legg–calvé–perthes Disease." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307669/all/Legg_calvé_perthes_Disease.
Legg–calvé–perthes Disease. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307669/all/Legg_calvé_perthes_Disease. Accessed May 29, 2023.
Legg–calvé–perthes Disease. (2016). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (5th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307669/all/Legg_calvé_perthes_Disease
Legg–calvé–perthes Disease [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2023 May 29]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307669/all/Legg_calvé_perthes_Disease.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Legg–calvé–perthes Disease ID - 307669 ED - Barkin,Adam Z, ED - Shayne,Philip, ED - Rosen,Peter, ED - Schaider,Jeffrey J, ED - Barkin,Roger M, ED - Hayden,Stephen R, ED - Wolfe,Richard E, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307669/all/Legg_calvé_perthes_Disease PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -