Periodic Paralysis
Periodic Paralysis is a topic covered in the 5-Minute Emergency Consult.
To view the entire topic, please sign in or purchase a subscription.
Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:
-- The first section of this topic is shown below --
Basics
Description
Description
- Periodic paralysis (PP): Disorder of muscle metabolism usually inherited that leads to flaccid extremity weakness. Exacerbated by hyperkalemia, hypokalemia, thyrotoxicosis
- Primary: Familial AD mutation skeletal muscle calcium, sodium, or potassium channel
- Secondary: Thyrotoxic, hypokalemia, hyperkalemia
Epidemiology
Incidence and Prevalence EstimatesEpidemiology
- Hypokalemic PP (HypoPP):
- MC, 1:100,000 prevalence
- 1/3 new AD mutations
- Hyperkalemic PP (HyperPP):
- 1:200,000 prevalence
- 90% of people with mutation will have clinical symptoms
- Thyrotoxic PP (ThyroPP):
- Incidence 2% in patients with thyrotoxicosis
- Higher in Asians
- Subset of HypoPP, clinically identical
- Andersen–Tawil:
- Subset of HypoPP
- Rare
- Prevalence unknown
Etiology
Etiology
- Mutation of skeletal muscle Na channel gene:
- SCN4A
- HypoPP, HyperPP:
- AD inheritance
- Spontaneous mutation
- Mutation of skeletal muscle calcium channel gene CACN1AS:
- HypoPP
- Mutation of KCNJ2 gene:
- Andersen–Tawil:
- AD inheritance
- 50% spontaneous
- Andersen–Tawil:
- M>F
- Age of onset:
- HypoPP:
- 1st or 2nd decade
- HyperPP:
- 1st decade
- Andersen–Tawil:
- 1st or 2nd decade
- ThyroPP:
- 2nd–5th decade
- HypoPP:
-- To view the remaining sections of this topic, please sign in or purchase a subscription --
Citation
Rosen, Peter, et al., editors. "Periodic Paralysis." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis.
Periodic Paralysis. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis. Accessed December 5, 2019.
Periodic Paralysis. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis
Periodic Paralysis [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 December 05]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Periodic Paralysis
ID - 307662
ED - Rosen,Peter,
ED - Shayne,Philip,
ED - Barkin,Adam Z,
ED - Wolfe,Richard E,
ED - Hayden,Stephen R,
ED - Barkin,Roger M,
ED - Schaider,Jeffrey J,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis
PB - Lippincott Williams & Wilkins
ET - 5
DB - Emergency Central
DP - Unbound Medicine
ER -