Type your tag names separated by a space and hit enter

Periodic Paralysis

Periodic Paralysis is a topic covered in the 5-Minute Emergency Consult.

To view the entire topic, please or purchase a subscription.

Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:

Emergency Central

-- The first section of this topic is shown below --



  • Periodic paralysis (PP): Disorder of muscle metabolism usually inherited that leads to flaccid extremity weakness. Exacerbated by hyperkalemia, hypokalemia, thyrotoxicosis
  • Primary: Familial AD mutation skeletal muscle calcium, sodium, or potassium channel
  • Secondary: Thyrotoxic, hypokalemia, hyperkalemia


Incidence and Prevalence Estimates
  • Hypokalemic PP (HypoPP):
    • MC, 1:100,000 prevalence
    • 1/3 new AD mutations
  • Hyperkalemic PP (HyperPP):
    • 1:200,000 prevalence
    • 90% of people with mutation will have clinical symptoms
  • Thyrotoxic PP (ThyroPP):
    • Incidence 2% in patients with thyrotoxicosis
    • Higher in Asians
    • Subset of HypoPP, clinically identical
  • Andersen–Tawil:
    • Subset of HypoPP
    • Rare
    • Prevalence unknown


  • Mutation of skeletal muscle Na channel gene:
    • SCN4A
    • HypoPP, HyperPP:
      • AD inheritance
      • Spontaneous mutation
  • Mutation of skeletal muscle calcium channel gene CACN1AS:
    • HypoPP
  • Mutation of KCNJ2 gene:
    • Andersen–Tawil:
      • AD inheritance
      • 50% spontaneous
  • M>F
  • Age of onset:
    • HypoPP:
      • 1st or 2nd decade
    • HyperPP:
      • 1st decade
    • Andersen–Tawil:
      • 1st or 2nd decade
    • ThyroPP:
      • 2nd–5th decade

-- To view the remaining sections of this topic, please or purchase a subscription --


Rosen, Peter, et al., editors. "Periodic Paralysis." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis.
Periodic Paralysis. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis. Accessed April 25, 2019.
Periodic Paralysis. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis
Periodic Paralysis [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 25]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Periodic Paralysis ID - 307662 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307662/all/Periodic_Paralysis PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -