Brugada Syndrome
Basics
Description
Description
- Inherited heart disease due to mutations of cardiac Na+ channels without structural abnormalities
- Very high risk of sudden cardiac death in the form of ventricular fibrillation
- 2-yr mortality ∼30%
- Suspected in 40–60% of what was previously known as idiopathic ventricular fibrillation
- Higher prevalence in men of Southeast Asian descent, but all ages, genders, races can be affected
Etiology
Etiology
- Inherited:
- Autosomal dominant in 50%
- Variable penetration
- Cardiac Na+ channel:
- >70 described mutations
- Variable penetrance
- SCN5A mutations account for 20%
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Citation
Schaider, Jeffrey J., et al., editors. "Brugada Syndrome." 5-Minute Emergency Consult, 6th ed., Lippincott Williams & Wilkins, 2020. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome.
Brugada Syndrome. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome. Accessed October 11, 2024.
Brugada Syndrome. (2020). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (6th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome
Brugada Syndrome [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. [cited 2024 October 11]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Brugada Syndrome
ID - 307636
ED - Barkin,Adam Z,
ED - Shayne,Philip,
ED - Rosen,Peter,
ED - Schaider,Jeffrey J,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome
PB - Lippincott Williams & Wilkins
ET - 6
DB - Emergency Central
DP - Unbound Medicine
ER -