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    Brugada Syndrome

    Brugada Syndrome is a topic covered in the 5-Minute Emergency Consult.

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    Emergency Central

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    Basics

    Description

    • Inherited heart disease due to mutations of cardiac Na+ channels without structural abnormalities
    • Very high risk of sudden cardiac death in the form of ventricular fibrillation
    • 2-yr mortality ∼30%
    • Suspected in 40–60% of what was previously known as idiopathic ventricular fibrillation
    • Higher prevalence in men of Southeast Asian descent, but all ages, genders, races can be affected

    Etiology

    • Inherited:
      • Autosomal dominant in 50%
      • Variable penetration
    • Cardiac Na+ channel:
      • >70 described mutations
      • Variable penetrance
      • SCN5A mutations account for 20%

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    Citation

    Rosen, Peter, et al., editors. "Brugada Syndrome." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome.
    Brugada Syndrome. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome. Accessed April 25, 2019.
    Brugada Syndrome. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome
    Brugada Syndrome [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 25]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome.
    * Article titles in AMA citation format should be in sentence-case
    TY - ELEC T1 - Brugada Syndrome ID - 307636 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307636/all/Brugada_Syndrome PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -