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Hazmat is a topic covered in the 5-Minute Emergency Consult.

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  • Hazmat refers to exposure to hazardous materials causing local or systemic toxicity.
  • Pathophysiology:
    • Acids cause coagulation necrosis with eschar, usually limiting penetration to deeper tissue.
    • Alkalis cause liquefaction necrosis and soluble complexes that penetrate into deep tissues.
    • Damage also occurs through oxidation, protein denaturation, cellular dehydration, local ischemia, and by metabolic competition/inhibition.


  • Hazardous materials are encountered in household, industry, agriculture, transportation accidents, and in criminal/terrorist activities.
  • The toxicity of the materials relates to the particular substances and their effects.

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* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Hazmat ID - 307615 ED - Barkin,Adam Z, ED - Barkin,Roger M, ED - Hayden,Stephen R, ED - Rosen,Peter, ED - Schaider,Jeffrey J, ED - Shayne,Philip, ED - Wolfe,Richard E, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307615/all/Hazmat PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -