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Sarcoidosis

Sarcoidosis is a topic covered in the 5-Minute Emergency Consult.

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Emergency Central

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Basics

Description

  • Chronic, multisystem disorder characterized by local accumulation of T lymphocytes and mononuclearphagocytes forming noncaseating epithelioid granulomas
  • Symptoms mainly due to organ dysfunction due to disruption of local tissue architecture:
    • Predominance of lung symptoms
  • ACE and Vitamin D levels may be increased due to secretion from granulomatous tissue
  • Prevalence 10–20/100,000 in US and Europe
  • Affects almost all races and geographic locations
  • Symptoms typically begin in patients 10–40 yr of age
  • 2.4% lifetime risk to blacks in US, relative to whites at 0.85%

Etiology

Unclear, but appears to be an overly robust cell-mediated immune response to unidentified self- or nonself antigen(s)

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Citation

Rosen, Peter, et al., editors. "Sarcoidosis." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307614/all/Sarcoidosis.
Sarcoidosis. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307614/all/Sarcoidosis. Accessed April 23, 2019.
Sarcoidosis. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307614/all/Sarcoidosis
Sarcoidosis [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 23]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307614/all/Sarcoidosis.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Sarcoidosis ID - 307614 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307614/all/Sarcoidosis PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -