5-Minute Emergency Consult
Sarcoidosis
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Basics
Description
- Chronic, multisystem disorder characterized by local accumulation of T lymphocytes and mononuclear phagocytes forming noncaseating epithelioid granulomas
- Symptoms mainly due to organ dysfunction due to disruption of local tissue architecture:
- Predominance of lung symptoms
- ACE and vitamin D levels (and thus calcium levels) may be increased due to secretion from granulomatous tissue
- Prevalence 10–20/100,000 in the U.S. and Europe
- Affects almost all races and geographic locations
- People of African descent higher predominance
- 2.4% lifetime risk to blacks in the U.S., whites 0.85%
- Symptoms typically begin in patients 10–40 yr of age
Etiology
Unclear, but appears to be an overly robust cell-mediated immune response to unidentified self- or nonself antigen(s). Familial clustering suggests genetic component
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Basics
Description
- Chronic, multisystem disorder characterized by local accumulation of T lymphocytes and mononuclear phagocytes forming noncaseating epithelioid granulomas
- Symptoms mainly due to organ dysfunction due to disruption of local tissue architecture:
- Predominance of lung symptoms
- ACE and vitamin D levels (and thus calcium levels) may be increased due to secretion from granulomatous tissue
- Prevalence 10–20/100,000 in the U.S. and Europe
- Affects almost all races and geographic locations
- People of African descent higher predominance
- 2.4% lifetime risk to blacks in the U.S., whites 0.85%
- Symptoms typically begin in patients 10–40 yr of age
Etiology
Unclear, but appears to be an overly robust cell-mediated immune response to unidentified self- or nonself antigen(s). Familial clustering suggests genetic component
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