5-Minute Emergency Consult
Nonsteroidal Anti-Inflammatory Poisoning
Basics
Description
Description
- Inhibit cyclooxygenase (COX), thereby blocking the conversion of arachidonic acid to prostaglandin
- Typically morbidity is low when an NSAID is ingested
- Most literature on nonselective NSAID toxicity involves ibuprofen exposure likely due to its OTC availability
- Fatalities have been reported with large ingestions
- Greater potential for toxicity with underlying CHF or renal failure:
- NSAIDs cause sodium and water retention and decrease renal blood flow
- Little overdose experience with the COX-2 inhibitors (celecoxib); treatment should be the same as for the traditional NSAIDs
Etiology
Etiology
- Nonsteroidal medications are available by prescription and over-the-counter
- NSAIDs include:
- Diclofenac
- Diflunisal
- Etodolac
- Fenoprofen
- Ibuprofen
- Indomethacin
- Ketoprofen
- Ketorolac
- Meclofenamate
- Mefenamic acid
- Meloxicam
- Nabumetone
- Naproxen
- Oxaprozin
- Piroxicam
- Sulindac
- Tolmetin
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Citation
Schaider, Jeffrey J., et al., editors. "Nonsteroidal Anti-Inflammatory Poisoning." 5-Minute Emergency Consult, 6th ed., Lippincott Williams & Wilkins, 2020. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307598/all/Nonsteroidal_Anti_Inflammatory_Poisoning.
Nonsteroidal Anti-Inflammatory Poisoning. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307598/all/Nonsteroidal_Anti_Inflammatory_Poisoning. Accessed October 15, 2024.
Nonsteroidal Anti-Inflammatory Poisoning. (2020). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (6th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307598/all/Nonsteroidal_Anti_Inflammatory_Poisoning
Nonsteroidal Anti-Inflammatory Poisoning [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2020. [cited 2024 October 15]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307598/all/Nonsteroidal_Anti_Inflammatory_Poisoning.
* Article titles in AMA citation format should be in sentence-case
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T1 - Nonsteroidal Anti-Inflammatory Poisoning
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ED - Barkin,Adam Z,
ED - Shayne,Philip,
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ED - Schaider,Jeffrey J,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307598/all/Nonsteroidal_Anti_Inflammatory_Poisoning
PB - Lippincott Williams & Wilkins
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DB - Emergency Central
DP - Unbound Medicine
ER -
