Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:
-- The first section of this topic is shown below --
- Gas gangrene or clostridial myonecrosis
- An acute, rapidly progressive, gas-forming necrotizing infection of muscle and subcutaneous tissue
- Can be seen in post-traumatic or postoperative situations
- Progressive invasion and destruction of healthy muscle tissue
- Clostridial organisms:
- Facultative anaerobic, spore-forming, gram-positive bacillus
- Produces a number of toxins; the most prevalent and lethal is α-toxin.
- Clostridium perfringens is the most common bacterium; found in 80–90% of wounds.
- Other clostridial bacteria include Clostridium novyi, Clostridium septicum, Clostridium histolyticum, Clostridium bifermentans, and Clostridium fallax.
- 2 distinct mechanisms for introduction of clostridial organisms:
- Traumatic and postoperative
- Nontraumatic associated with diabetes mellitus, peripheral vascular disease, alcoholism, IV drug abuse, and malignancies