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Barbiturates Poisoning

Barbiturates Poisoning is a topic covered in the 5-Minute Emergency Consult.

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Basics

Description

  • Class of sedative–hypnotic agents
  • Derivatives of barbituric acid
  • Mechanism:
    • Enhances activity of γ-aminobutyric acid (GABA)
    • At high levels, directly opens GABA-A associated chloride channel
    • Leads to inhibition of vascular smooth muscle tone
    • May lead to direct myocardial depression

Etiology

Overdose of barbiturates:
  • Intentional or nonintentional

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Citation

Rosen, Peter, et al., editors. "Barbiturates Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning.
Barbiturates Poisoning. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning. Accessed April 22, 2019.
Barbiturates Poisoning. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning
Barbiturates Poisoning [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 22]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Barbiturates Poisoning ID - 307529 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307529/all/Barbiturates_Poisoning PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -