Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:
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- Potentiates the activity of γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter, by binding to its own specific site
- Also facilitates GABA binding to its site
- Results in chloride influx, membrane hyperpolarization, and inhibition of cellular excitation:
- Benzodiazepines (BZDs) increase the frequency of chloride channel opening.
- Depresses spinal reflexes and reticular activating system
- Rapidly absorbed from GI tract:
- Highly protein bound
- Large Vd
- Hepatic metabolism
- Duration of action is inversely proportional to lipophilicity with highly lipophilic drugs penetrating the CNS more rapidly.
- Duration of lorazepam > diazepam > midazolam.
- Synergistic with other sedative–hypnotic medications (e.g., ethanol, barbiturates, propofol)