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Withdrawal, Drug

Withdrawal, Drug is a topic covered in the 5-Minute Emergency Consult.

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Basics

Description

  • Neuroexcitation is the hallmark of benzodiazepine, barbiturate, and opiate withdrawal
  • Benzodiazepine and barbiturate withdrawal can be life threatening
  • Opiate withdrawal can be extremely uncomfortable but is not typically life threatening
  • Cocaine and amphetamine withdrawal are similarly not life threatening

Etiology

  • Chronic exposure to certain drugs cause adaptive changes in the CNS
  • Withdrawal syndromes occur when the constant presence of drug is removed or reduced and the adaptive changes persist
  • Tolerance occurs when increasing amounts of drug are required to achieve a given response
  • Withdrawal and tolerance are distinct entities

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Citation

Rosen, Peter, et al., editors. "Withdrawal, Drug." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307514/all/Withdrawal__Drug.
Withdrawal, Drug. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307514/all/Withdrawal__Drug. Accessed April 25, 2019.
Withdrawal, Drug. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307514/all/Withdrawal__Drug
Withdrawal, Drug [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 25]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307514/all/Withdrawal__Drug.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Withdrawal, Drug ID - 307514 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307514/all/Withdrawal__Drug PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -