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Beta-Blocker Poisoning

Beta-Blocker Poisoning is a topic covered in the 5-Minute Emergency Consult.

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Basics

Description

Normal Physiology
  • Cardiovascular: β1-receptors:
    • ATP converted to cAMP by adenyl cyclase with stimulation of β-receptors.
    • cAMP activates protein kinase, which phosphorylates proteins of the sarcoplasmic reticulum.
    • Sarcoplasmic reticulum releases calcium.
    • Excitation–contraction coupling occurs.
  • Effects of β-blockers:
    • Cardiovascular:
      • Decreased excitation/contraction
      • Membrane stabilizing activity
      • Sodium channel blockade causes a prolongation of the QRS complex (with some agents).
      • Prolongation of QTc interval leading to ventricular dysrhythmias (with some agents)
      • Intrinsic sympathomimetic activity
      • Partial agonist properties (with some agents)
    • Neurologic:
      • CNS effects with the lipophilic agents (propranolol, metoprolol, labetalol)

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Citation

Rosen, Peter, et al., editors. "Beta-Blocker Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/all/Beta_Blocker_Poisoning.
Beta-Blocker Poisoning. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/all/Beta_Blocker_Poisoning. Accessed April 25, 2019.
Beta-Blocker Poisoning. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/all/Beta_Blocker_Poisoning
Beta-Blocker Poisoning [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 25]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/all/Beta_Blocker_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Beta-Blocker Poisoning ID - 307509 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/all/Beta_Blocker_Poisoning PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -