5-Minute Emergency Consult
Beta-Blocker Poisoning
Beta-Blocker Poisoning is a topic covered in the 5-Minute Emergency Consult.
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Basics
Description
Normal PhysiologyDescription
- Cardiovascular: β1-receptors:
- ATP converted to cAMP by adenyl cyclase with stimulation of β-receptors
- cAMP activates protein kinase, which phosphorylates proteins of the sarcoplasmic reticulum
- Sarcoplasmic reticulum releases calcium
- Excitation–contraction coupling occurs
- Effects of β-blockers:
- Cardiovascular:
- Decreased excitation/contraction
- Membrane stabilizing activity
- Sodium channel blockade causes a prolongation of the QRS complex (with some agents)
- Prolongation of QTc interval leading to ventricular dysrhythmias (with some agents)
- Intrinsic sympathomimetic activity
- Partial agonist properties (with some agents)
- Neurologic:
- CNS effects with the lipophilic agents (propranolol, metoprolol, labetalol)
- Cardiovascular:
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Basics
Description
Normal PhysiologyDescription
- Cardiovascular: β1-receptors:
- ATP converted to cAMP by adenyl cyclase with stimulation of β-receptors
- cAMP activates protein kinase, which phosphorylates proteins of the sarcoplasmic reticulum
- Sarcoplasmic reticulum releases calcium
- Excitation–contraction coupling occurs
- Effects of β-blockers:
- Cardiovascular:
- Decreased excitation/contraction
- Membrane stabilizing activity
- Sodium channel blockade causes a prolongation of the QRS complex (with some agents)
- Prolongation of QTc interval leading to ventricular dysrhythmias (with some agents)
- Intrinsic sympathomimetic activity
- Partial agonist properties (with some agents)
- Neurologic:
- CNS effects with the lipophilic agents (propranolol, metoprolol, labetalol)
- Cardiovascular:
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Citation
Schaider, Jeffrey J., et al., editors. "Beta-Blocker Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/2.3/Beta_Blocker_Poisoning.
Beta-Blocker Poisoning. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/2.3/Beta_Blocker_Poisoning. Accessed March 30, 2023.
Beta-Blocker Poisoning. (2016). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (5th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/2.3/Beta_Blocker_Poisoning
Beta-Blocker Poisoning [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2023 March 30]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307509/2.3/Beta_Blocker_Poisoning.
* Article titles in AMA citation format should be in sentence-case
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ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
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