5-Minute Emergency Consult
Digoxin, Poisoning
Digoxin, Poisoning is a topic covered in the 5-Minute Emergency Consult.
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Basics
Description
Description
- Acute digitalis effects (elevated levels in children and intentional overdose):
- Inhibits sodium–potassium ATPase pump in cell membranes
- Increased intracellular calcium
- Increases K+ extracellularly
- Increases vagal tone
- Slows atrioventricular (AV) node conduction (vagotonic)
- Increases automaticity and conduction system refractory period
- Bradydysrhythmias
- Chronic digitalis effects (therapeutic to toxic levels in elderly patients):
- Inhibits sodium–potassium ATPase pump in cell membranes
- Increases intracellular calcium
- Increases vagal tone
- Increases automaticity
- Usually hypokalemic secondary to diuretic use
- Tachydysrhythmias
Etiology
Etiology
- Digoxin/pharmaceuticals
- Plants and animals containing cardiac glycosides:
- Foxglove
- Oleander (white and yellow)
- Lily of the valley
- Red squill
- Cane toad, Colorado River toad
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Basics
Description
Description
- Acute digitalis effects (elevated levels in children and intentional overdose):
- Inhibits sodium–potassium ATPase pump in cell membranes
- Increased intracellular calcium
- Increases K+ extracellularly
- Increases vagal tone
- Slows atrioventricular (AV) node conduction (vagotonic)
- Increases automaticity and conduction system refractory period
- Bradydysrhythmias
- Chronic digitalis effects (therapeutic to toxic levels in elderly patients):
- Inhibits sodium–potassium ATPase pump in cell membranes
- Increases intracellular calcium
- Increases vagal tone
- Increases automaticity
- Usually hypokalemic secondary to diuretic use
- Tachydysrhythmias
Etiology
Etiology
- Digoxin/pharmaceuticals
- Plants and animals containing cardiac glycosides:
- Foxglove
- Oleander (white and yellow)
- Lily of the valley
- Red squill
- Cane toad, Colorado River toad
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Citation
Schaider, Jeffrey J., et al., editors. "Digoxin, Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307493/all/Digoxin__Poisoning.
Digoxin, Poisoning. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307493/all/Digoxin__Poisoning. Accessed March 28, 2023.
Digoxin, Poisoning. (2016). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (5th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307493/all/Digoxin__Poisoning
Digoxin, Poisoning [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2023 March 28]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307493/all/Digoxin__Poisoning.
* Article titles in AMA citation format should be in sentence-case
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ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
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PB - Lippincott Williams & Wilkins
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