- Disruption of the seal between the nail plate and the nail fold may allow entry of bacteria into the eponychial space
- Inflammation of the nail folds surrounding the nail plate
- Acute paronychia: Predominantly Staphylococcus aureus but also streptococci, Pseudomonas, and anaerobes
- Chronic paronychia: Multifactorial due to allergens and irritants in addition to fungal etiologies, predominantly Candida albicans, which commonly coexist with Staphylococcus species
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