Arthritis, Rheumatoid
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Basics
Description
- Chronic systemic inflammatory disorder that attacks the joints:
- Nonsuppurative, proliferative synovitis
- Destruction of the articular cartilage
- Ankylosis of the joint
- Involvement of knee is common
- Baker cysts may be seen in chronic disease
- Involvement of spine is limited to cervical region:
- May cause atlantoaxial subluxation
- Rarely results in cord compression
Pediatric Considerations
Juvenile rheumatoid arthritis (JRA) is a distinct entity (see “Arthritis, Juvenile Idiopathic”)
- Genetics:
- Genetic predisposition related to HLA-DR4
- Female-to-male ratio is 3:1
- Typical age of onset is between 30–50
Etiology
- Etiology is unknown
- Possible triggers include infection and autoimmune response
- Prevalence is about 1% of both U.S. and world population
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Basics
Description
- Chronic systemic inflammatory disorder that attacks the joints:
- Nonsuppurative, proliferative synovitis
- Destruction of the articular cartilage
- Ankylosis of the joint
- Involvement of knee is common
- Baker cysts may be seen in chronic disease
- Involvement of spine is limited to cervical region:
- May cause atlantoaxial subluxation
- Rarely results in cord compression
Pediatric Considerations
Juvenile rheumatoid arthritis (JRA) is a distinct entity (see “Arthritis, Juvenile Idiopathic”)
- Genetics:
- Genetic predisposition related to HLA-DR4
- Female-to-male ratio is 3:1
- Typical age of onset is between 30–50
Etiology
- Etiology is unknown
- Possible triggers include infection and autoimmune response
- Prevalence is about 1% of both U.S. and world population
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