• The proximal bowel invaginates into the distal bowel, producing infarction and gangrene of the inner bowel:
    • >80% involve the ileocecal region
  • Often occurs with a pathologic lead point in children >2 yr:
    • Hypertrophied lymphoid patches may be present in infants
    • Children >2 yr: 1/3 of patients have pathologic lead point
    • Children >6 yr: Lymphoma is the most common lead point
    • Adults usually have a pathologic lead point
  • The most common cause of intestinal obstruction within the first 2 yr of life
  • Epidemiology in the U.S.:
    • Most frequently between 5–9 mo of age
    • Incidence is 2.4 cases per 1,000 live births
    • Male > female predominance of 2:1
    • Mortality <1%
  • Morbidity increases with delayed diagnosis

Patients, particularly those in the pediatric age group, with a picture of potential intestinal obstruction, especially with hematest-positive stool or altered mental status, need to have intussusception considered


  • Most cases (85%) have no apparent underlying pathology
  • Predisposing conditions that create a lead point for invagination, esp in children <3 mo, those >5 yr of age and adults:
    • Masses/tumors:
      • Lymphoma
      • Lipoma
      • Polyp
      • Hypertrophied lymphoid patches
      • Meckel diverticulum
    • Infection:
      • Adenovirus or rotavirus infection
      • Parasites
    • Foreign body
    • Henoch–Schönlein purpura
    • Celiac disease and cystic fibrosis (small intestine intussusception)

There's more to see -- the rest of this topic is available only to subscribers.