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Intussusception is a topic covered in the 5-Minute Emergency Consult.

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  • The proximal bowel invaginates into the distal bowel, producing infarction and gangrene of the inner bowel:
    • >80% involve the ileocecal region.
  • Often occurs with a pathologic lead point in children >2 yr:
    • Hypertrophied lymphoid patches may be present in infants.
    • Children >2 yr: 1/3 of patients have pathologic lead point.
    • Children >6 yr: Lymphoma is the most common lead point.
    • Adults usually have a pathologic lead point.
  • The most common cause of intestinal obstruction within the 1st 2 yr of life
  • Epidemiology in US:
    • Most frequently between 5 and 9 mo of age
    • Incidence is 2.4 cases per 1,000 live births.
    • Male > female predominance of 2:1
    • Mortality <1%
  • Morbidity increases with delayed diagnosis.

Patients, particularly those in the pediatric age group, with a picture of potential intestinal obstruction, especially with hematest-positive stool or altered mental status, need to have intussusception considered.


  • Most cases (85%) have no apparent underlying pathology.
  • Predisposing conditions that create a lead point for invagination, esp. in older children and adults:
    • Masses/tumors:
      • Lymphoma
      • Lipoma
      • Polyp
      • Hypertrophied lymphoid patches
      • Meckel diverticulum
    • Infection:
      • Adenovirus or rotavirus infection
      • Parasites
    • Foreign body
    • Henoch–Schönlein purpura
    • Celiac disease and cystic fibrosis (small intestine intussusception)

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Rosen, Peter, et al., editors. "Intussusception." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307375/all/Intussusception.
Intussusception. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307375/all/Intussusception. Accessed April 25, 2019.
Intussusception. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307375/all/Intussusception
Intussusception [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 25]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307375/all/Intussusception.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Intussusception ID - 307375 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307375/all/Intussusception PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -