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Mdma Poisoning

Mdma Poisoning is a topic covered in the 5-Minute Emergency Consult.

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  • MDMA: 3,4-methylenedioxymethamphetamine (“ecstasy”)
  • Schedule I drug manufactured illegally
  • Used recreationally:
    • Rave parties
    • Dance clubs
    • College campuses
  • Onset of effects: 15–30 min after ingestion
  • Duration of effects: 2–6 hr
  • Pills commonly contain contaminants:
    • Caffeine
    • Ephedrine
    • Dextromethorphan
    • Ketamine
    • Related methylated amphetamines: 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-ethylamphetamine (MDEA), 3,4-methylenedioxy-N-butylamphetamine (MDBA), para-methoxyamphetamine (PMA)
  • Pathophysiology:
    • Amphetamine-like structure stimulates catecholamine release.
    • Mescaline-like ring structure enhances serotonergic and dopaminergic activity.


Deliberate or accidental ingestion of MDMA

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Rosen, Peter, et al., editors. "Mdma Poisoning." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307339/all/Mdma_Poisoning.
Mdma Poisoning. In: Rosen P, Shayne P, Barkin AZ, et al, eds. 5-Minute Emergency Consult. 5th ed. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307339/all/Mdma_Poisoning. Accessed April 23, 2019.
Mdma Poisoning. (2016). In Rosen, P., Shayne, P., Barkin, A. Z., Wolfe, R. E., Hayden, S. R., Barkin, R. M., & Schaider, J. J. (Eds.), 5-Minute Emergency Consult. Available from https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307339/all/Mdma_Poisoning
Mdma Poisoning [Internet]. In: Rosen P, Shayne P, Barkin AZ, Wolfe RE, Hayden SR, Barkin RM, Schaider JJ, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2019 April 23]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307339/all/Mdma_Poisoning.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Mdma Poisoning ID - 307339 ED - Rosen,Peter, ED - Shayne,Philip, ED - Barkin,Adam Z, ED - Wolfe,Richard E, ED - Hayden,Stephen R, ED - Barkin,Roger M, ED - Schaider,Jeffrey J, BT - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307339/all/Mdma_Poisoning PB - Lippincott Williams & Wilkins ET - 5 DB - Emergency Central DP - Unbound Medicine ER -