Bundle Branch Blocks

Basics

Description

  • Impaired ventricular conduction through His–Purkinje bundles
  • Incomplete bundle branch block:
    • Partial delay in conduction down one bundle
    • Quasi-random signal (QRS) complex duration of 100–120 ms
  • Complete bundle branch block:
    • Absence or delay of conduction down one bundle, with normal conduction down the other bundle
    • Affected ventricle depolarizes from muscle to muscle in a slower and more disorganized fashion
    • QRS complex at 120 ms or longer
  • Right bundle branch block (RBBB):
    • Delayed depolarization of the right ventricle causing the right ventricle to depolarize via slower, muscle-to-muscle conduction
  • Left bundle branch block (LBBB):
    • Delayed depolarization of the left ventricle
    • Left bundle branches into 2 fascicles:
      • Left anterior fascicle: Initial septal activation proceeds inferiorly, anteriorly, and to the right
      • Left posterior fascicle: Isolated blockage rare; activation begins in the midseptum and finishes in inferior and posterior walls
    • LBBB can be caused by delay of conduction in main left bundle or delay in both fascicles of the left bundle
    • Causes early activation of the right side of the septum and the right ventricular myocardium (so explaining loss of “septal Q” on ECG)
  • Bifascicular block:
    • RBBB with concomitant block of the left anterior or left posterior fascicle

Etiology

  • Myocardial infarction
  • Cardiomyopathy
  • Myocarditis
  • Pulmonary embolism
  • Cor pulmonale
  • Chronic obstructive pulmonary disease
  • Obstructive sleep apnea
  • Hypertension
  • Age-related fibrosis of Purkinje fibers
  • Myocardial Ischemia (myocarditis)
  • Valvular heart disease
  • Congenital/atrial septal defect
  • Progressive cardiac conduction disease
  • Chagas disease (Central/South American predominance)
  • Rheumatic fever
  • Infectious endocarditis
  • Tuberculosis involving the pericardium or myocardium
  • Postoperative/Iatrogenic following cardiac procedures
  • Amyloidosis
  • Sarcoidosis
  • Hemachromatosis
  • Systemic lupus erythematosus
  • Radiation therapy
  • Drugs:
    • β-Blockers
    • Calcium blockers
    • Tricyclic antidepressants
    • Type Ia and Ic antiarrhythmics
    • Digitalis

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