Carpal Tunnel Syndrome
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Basics
Description
- Carpal tunnel syndrome (CTS) is caused by compression of the median nerve as it passes through the carpal tunnel
- Results in pain, paresthesias, and sometimes weakness in the hand
- Can be acute or chronic
- The carpal tunnel is bound by the carpal bones and the transverse carpal ligament (flexor retinaculum)
- The median nerve and tendons of flexor digitorum profundus (FDP), flexor digitorum superficialis (FDS), and flexor pollicis longus pass through the carpal tunnel
- Prevalence: 1–5%; women > men
Etiology
- Acute:
- Trauma (particularly with distal radius and carpal fractures)
- Infection (cellulitis, septic arthritis, viral syndrome)
- Inflammatory (gout, rheumatoid arthritis)
- Hemorrhage
- Iatrogenic
- Chronic:
- Occupational/overuse syndromes – high impact, repetitive motion
- Trauma can have delayed presentation from median nerve contusion or alteration in anatomy from atypical healing
- Pregnancy, birth control pills, aromatase inhibitors
- Granulomatous disease: Tuberculosis, sarcoidosis
- Mass lesions with median nerve compression
- Anatomic anomalies (e.g., persistent median artery, venous malformation)
- Amyloidosis
- Endocrine disorders: Hypothyroidism, diabetes mellitus, acromegaly
- Chronic hemodialysis
- Idiopathic
Pediatric Considerations
Rare in children; most common causes:
- Trauma
- Mucolipidosis and mucopolysaccharidosis
- Hemophilia with wrist hematoma
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Carpal tunnel syndrome (CTS) is caused by compression of the median nerve as it passes through the carpal tunnel
- Results in pain, paresthesias, and sometimes weakness in the hand
- Can be acute or chronic
- The carpal tunnel is bound by the carpal bones and the transverse carpal ligament (flexor retinaculum)
- The median nerve and tendons of flexor digitorum profundus (FDP), flexor digitorum superficialis (FDS), and flexor pollicis longus pass through the carpal tunnel
- Prevalence: 1–5%; women > men
Etiology
- Acute:
- Trauma (particularly with distal radius and carpal fractures)
- Infection (cellulitis, septic arthritis, viral syndrome)
- Inflammatory (gout, rheumatoid arthritis)
- Hemorrhage
- Iatrogenic
- Chronic:
- Occupational/overuse syndromes – high impact, repetitive motion
- Trauma can have delayed presentation from median nerve contusion or alteration in anatomy from atypical healing
- Pregnancy, birth control pills, aromatase inhibitors
- Granulomatous disease: Tuberculosis, sarcoidosis
- Mass lesions with median nerve compression
- Anatomic anomalies (e.g., persistent median artery, venous malformation)
- Amyloidosis
- Endocrine disorders: Hypothyroidism, diabetes mellitus, acromegaly
- Chronic hemodialysis
- Idiopathic
Pediatric Considerations
Rare in children; most common causes:
- Trauma
- Mucolipidosis and mucopolysaccharidosis
- Hemophilia with wrist hematoma
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