Cushing Syndrome
Basics
Description
Description
- Cushing disease: Pituitary adenoma producing excess adrenocorticotropic hormone (ACTH)
- Cushing syndrome: Excessive glucocorticoid effects
Risk Factors
GeneticsRisk Factors
- Multiple endocrine neoplasia (MEN) type I
- Carney complex (pigmented lentigines, atrial myxoma, germ-cell tumors with Cushing disease)
Etiology
Etiology
- Most commonly exogenous administration of glucocorticoids either therapeutically or surreptitiously
- Pituitary adenoma secreting ACTH
- Adrenal production of cortisol from adenoma, carcinoma, or micronodular disease
- Tumor-producing ectopic ACTH:
- Small cell lung carcinoma:
- Most common
- Uterine cervical carcinoma
- Islet cell tumor of pancreas:
- Multiple endocrine neoplasia (MEN) type I syndrome
- Medullary thyroid cancer
- Pheochromocytoma
- Ganglioneuroma
- Melanoma prostate carcinoma
- Carcinoid tumor:
- Lung
- Pancreas
- GI tract
- Thymus
- Ovary
- Small cell lung carcinoma:
There's more to see -- the rest of this topic is available only to subscribers.
Citation
Schaider, Jeffrey J., et al., editors. "Cushing Syndrome." 5-Minute Emergency Consult, 5th ed., Lippincott Williams & Wilkins, 2016. Emergency Central, emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome.
Cushing Syndrome. In: Schaider JJJ, Barkin RMR, Hayden SRS, et al, eds. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome. Accessed August 31, 2024.
Cushing Syndrome. (2016). In Schaider, J. J., Barkin, R. M., Hayden, S. R., Wolfe, R. E., Barkin, A. Z., Shayne, P., & Rosen, P. (Eds.), 5-Minute Emergency Consult (5th ed.). Lippincott Williams & Wilkins. https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome
Cushing Syndrome [Internet]. In: Schaider JJJ, Barkin RMR, Hayden SRS, Wolfe RER, Barkin AZA, Shayne PP, Rosen PP, editors. 5-Minute Emergency Consult. Lippincott Williams & Wilkins; 2016. [cited 2024 August 31]. Available from: https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Cushing Syndrome
ID - 307292
ED - Barkin,Adam Z,
ED - Shayne,Philip,
ED - Rosen,Peter,
ED - Schaider,Jeffrey J,
ED - Barkin,Roger M,
ED - Hayden,Stephen R,
ED - Wolfe,Richard E,
BT - 5-Minute Emergency Consult
UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome
PB - Lippincott Williams & Wilkins
ET - 5
DB - Emergency Central
DP - Unbound Medicine
ER -