Cushing Syndrome is a topic covered in the 5-Minute Emergency Consult.

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Basics

Description

  • Cushing disease: Pituitary adenoma producing excess adrenocorticotropic hormone (ACTH)
  • Cushing syndrome: Excessive glucocorticoid effects

Risk Factors

Genetics
  • Multiple endocrine neoplasia type I
  • Carney complex (pigmented lentigines, atrial myxoma, germ-cell tumors with Cushing disease)

Etiology

  • Most commonly exogenous administration of glucocorticoids either therapeutically or surreptitiously
  • Pituitary adenoma secreting ACTH
  • Adrenal production of cortisol from adenoma, carcinoma, or micronodular disease
  • Tumor-producing ectopic ACTH:
    • Small cell lung carcinoma:
      • Most common
    • Uterine cervical carcinoma
    • Islet cell tumor of pancreas:
      • Multiple endocrine neoplasia (MEN) I-type syndrome
    • Medullary thyroid cancer
    • Pheochromocytoma
    • Ganglioneuroma
    • Melanoma prostate carcinoma
    • Carcinoid tumor:
      • Lung
      • Pancreas
      • GI tract
      • Thymus
      • Ovary

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Citation

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TY - ELEC T1 - Cushing Syndrome ID - 307292 Y1 - 2016 PB - 5-Minute Emergency Consult UR - https://emergency.unboundmedicine.com/emergency/view/5-Minute_Emergency_Consult/307292/all/Cushing_Syndrome ER -