Cushing Syndrome

Cushing Syndrome is a topic covered in the 5-Minute Emergency Consult.

To view the entire topic, please or purchase a subscription.

Emergency Central is a collection of disease, drug, and test information including 5-Minute Emergency Medicine Consult, Davis’s Drug, McGraw-Hill Medical’s Diagnosaurus®, Pocket Guide to Diagnostic Tests, and MEDLINE Journals created for emergency medicine professionals. Explore these free sample topics:

Emergency Central

-- The first section of this topic is shown below --

Basics

Description

  • Cushing disease: Pituitary adenoma producing excess adrenocorticotropic hormone (ACTH)
  • Cushing syndrome: Excessive glucocorticoid effects

Risk Factors

Genetics
  • Multiple endocrine neoplasia type I
  • Carney complex (pigmented lentigines, atrial myxoma, germ-cell tumors with Cushing disease)

Etiology

  • Most commonly exogenous administration of glucocorticoids either therapeutically or surreptitiously
  • Pituitary adenoma secreting ACTH
  • Adrenal production of cortisol from adenoma, carcinoma, or micronodular disease
  • Tumor-producing ectopic ACTH:
    • Small cell lung carcinoma:
      • Most common
    • Uterine cervical carcinoma
    • Islet cell tumor of pancreas:
      • Multiple endocrine neoplasia (MEN) I-type syndrome
    • Medullary thyroid cancer
    • Pheochromocytoma
    • Ganglioneuroma
    • Melanoma prostate carcinoma
    • Carcinoid tumor:
      • Lung
      • Pancreas
      • GI tract
      • Thymus
      • Ovary

-- To view the remaining sections of this topic, please or purchase a subscription --