Delirium
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Basics
Description
- Delirium is a clinical syndrome characterized by acute changes in awareness, cognition, and perception with a waxing and waning course
- Delirium is often secondary to an underlying acute medical condition
- Pathophysiology unknown:
- Diffuse cerebral dysfunction
- Derangements of cerebral acetylcholine
- CNS dopamine, γ-aminobutyric acid, and serotonin may be involved
- Frequently missed by emergency medicine physicians
- Associated with increased mortality, increased admission, and increased length of stay
Etiology
- Neurologic:
- Meningitis or encephalitis
- Seizure
- Wernicke encephalopathy
- Hypoxia and hypoperfusion of the brain
- Intracranial bleed or mass
- Stroke syndrome
- Pulmonary:
- Pneumonia
- Other pulmonary etiology of hypoxia or hypercapnia
- Cardiovascular:
- Hypertensive crisis
- Acute coronary syndromes
- Arrhythmia
- GI:
- Hepatic encephalopathy
- Dehydration
- Renal:
- UTI
- Acute renal failure
- Endocrine:
- Hypoglycemia
- Hyperglycemia
- Hypothyroid
- Rheumatologic:
- Collagen vascular disorder
- Toxicologic:
- Medications or supplements
- Withdrawal from barbiturates or alcohol
- Environmental toxins
- Other:
- Electrolyte abnormalities
- Vitamin deficiencies
- Hypothermia
- Hyperthermia
- Trauma
- Surgery
Geriatric Considerations
- Common presentation in older ED patients
- Up to 10% of older ED patients may have delirium
- Many patients will present with subtle symptoms and vague chief complaints:
- Fall, dizzy, or not feeling well
- Waxing and waning symptoms
- Patients with known dementia are prone to develop delirium from acute medical conditions
- Life-threatening condition
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Delirium is a clinical syndrome characterized by acute changes in awareness, cognition, and perception with a waxing and waning course
- Delirium is often secondary to an underlying acute medical condition
- Pathophysiology unknown:
- Diffuse cerebral dysfunction
- Derangements of cerebral acetylcholine
- CNS dopamine, γ-aminobutyric acid, and serotonin may be involved
- Frequently missed by emergency medicine physicians
- Associated with increased mortality, increased admission, and increased length of stay
Etiology
- Neurologic:
- Meningitis or encephalitis
- Seizure
- Wernicke encephalopathy
- Hypoxia and hypoperfusion of the brain
- Intracranial bleed or mass
- Stroke syndrome
- Pulmonary:
- Pneumonia
- Other pulmonary etiology of hypoxia or hypercapnia
- Cardiovascular:
- Hypertensive crisis
- Acute coronary syndromes
- Arrhythmia
- GI:
- Hepatic encephalopathy
- Dehydration
- Renal:
- UTI
- Acute renal failure
- Endocrine:
- Hypoglycemia
- Hyperglycemia
- Hypothyroid
- Rheumatologic:
- Collagen vascular disorder
- Toxicologic:
- Medications or supplements
- Withdrawal from barbiturates or alcohol
- Environmental toxins
- Other:
- Electrolyte abnormalities
- Vitamin deficiencies
- Hypothermia
- Hyperthermia
- Trauma
- Surgery
Geriatric Considerations
- Common presentation in older ED patients
- Up to 10% of older ED patients may have delirium
- Many patients will present with subtle symptoms and vague chief complaints:
- Fall, dizzy, or not feeling well
- Waxing and waning symptoms
- Patients with known dementia are prone to develop delirium from acute medical conditions
- Life-threatening condition
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