Congenital Heart Disease, Cyanotic
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Basics
Description
- Aberrant embryonic development results in mixing of deoxygenated and oxygenated blood returning to systemic circulation by 2 mechanisms:
- Right-to-left intracardiac shunt
- Anatomic defects of the aortic root
- Subtypes: 5 T's, 2 E's, single ventricle:
- Tetralogy of Fallot (TOF):
- Ventricular septal defect (VSD)
- Right ventricular (RV) outflow obstruction
- Overriding aorta
- RV hypertrophy (RVH)
- Transposition of the great arteries (TGA):
- Aorta arises from RV and pulmonary artery from left ventricle (LV)
- Tricuspid atresia:
- No outlet from right atrium to RV
- Obligatory atrial level connection
- Truncus arteriosus:
- Single arterial trunk for systemic, pulmonic, and carotid circulations
- Total anomalous pulmonary venous return (TAPVR):
- Pulmonary veins drain into systemic venous circulation
- Supracardiac, cardiac, infracardiac, or mixed
- Ebstein anomaly of tricuspid valve:
- Abnormal and displaced tricuspid valve divides RV resulting in poor RV function
- Eisenmenger syndrome:
- Complication in longstanding acyanotic heart disease with L→R shunts
- Pulmonary vascular resistance reaches suprasystemic levels; R→L shunt
- Single ventricle physiology:
- Total mixing of systemic and venous return
- Tetralogy of Fallot (TOF):
- Subdivide by amount of pulmonary blood flow:
- Decreased in TOF and tricuspid atresia
- Increased in TGA, truncus, and TAPVR
Etiology
For most forms, cause is unknown:- Genetic cause: Chromosome 22 deletion in DiGeorge syndrome (conotruncal defects; TOF, truncus; also coarctation of aorta)
- Environmental/teratogenic: TGA seen more often in infants of diabetic mothers
-- To view the remaining sections of this topic, please log in or purchase a subscription --
Basics
Description
- Aberrant embryonic development results in mixing of deoxygenated and oxygenated blood returning to systemic circulation by 2 mechanisms:
- Right-to-left intracardiac shunt
- Anatomic defects of the aortic root
- Subtypes: 5 T's, 2 E's, single ventricle:
- Tetralogy of Fallot (TOF):
- Ventricular septal defect (VSD)
- Right ventricular (RV) outflow obstruction
- Overriding aorta
- RV hypertrophy (RVH)
- Transposition of the great arteries (TGA):
- Aorta arises from RV and pulmonary artery from left ventricle (LV)
- Tricuspid atresia:
- No outlet from right atrium to RV
- Obligatory atrial level connection
- Truncus arteriosus:
- Single arterial trunk for systemic, pulmonic, and carotid circulations
- Total anomalous pulmonary venous return (TAPVR):
- Pulmonary veins drain into systemic venous circulation
- Supracardiac, cardiac, infracardiac, or mixed
- Ebstein anomaly of tricuspid valve:
- Abnormal and displaced tricuspid valve divides RV resulting in poor RV function
- Eisenmenger syndrome:
- Complication in longstanding acyanotic heart disease with L→R shunts
- Pulmonary vascular resistance reaches suprasystemic levels; R→L shunt
- Single ventricle physiology:
- Total mixing of systemic and venous return
- Tetralogy of Fallot (TOF):
- Subdivide by amount of pulmonary blood flow:
- Decreased in TOF and tricuspid atresia
- Increased in TGA, truncus, and TAPVR
Etiology
For most forms, cause is unknown:- Genetic cause: Chromosome 22 deletion in DiGeorge syndrome (conotruncal defects; TOF, truncus; also coarctation of aorta)
- Environmental/teratogenic: TGA seen more often in infants of diabetic mothers
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